Biochem/physiol Actions

Cell permeable: no

Reversible: no

Primary TargetActivate DEVD-cleaving caspases

Product does not compete with ATP.

General description

A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent. Induces apoptosis in tumor cells, sensitizes tumor cells to TNF-α-induced activation of NF-κB. Also inhibits IL-2 expression in activated T-cells at the level of purine-box/nuclear factor and NF-κB transcriptional activation. Also reported to inhibit mitogen activated protein kinase phosphatase-1 (MKP-1). Reported to induce apoptosis by activating DEVD-cleaving caspases.

A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent. Induces apoptosis in tumor cells by activating DEVD-cleaving caspases. Sensitizes tumor cells to TNF-α-induced apoptosis, and inhibits TNF-α-induced activation of NF-κB. Also inhibits T cell IL-2 expression at the level of purine-box/nuclear factor of activated T cells and NF-κB transcriptional activation. Also reported to inhibit mitogen activated protein kinase phosphatase-1 (MKP-1).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Zhao, Q., et al. 2005. J. Biol. Chem.280, 8101.Shepherd, E., et al. 2004. J. Biol. Chem.279, 54023.Chan, M.A., et al. 1999. Phytother. Res. 13, 464.Lee, K.Y., et al. 1999. J. Biol. Chem. 274, 13451.Qiu, D., et al. 1999. J. Biol. Chem. 274, 13443.Yang, Y., et al. 1998. Immunopharmacology40, 139.

Packaging

1, 5 mg in Plastic ampoule

Packaged under inert gas

Warning

Toxicity: Harmful & Carcinogenic / Teratogenic (E)